Let's get to the weekly picks ...
* Boston College at Florida State (Noon, ESPN): Seminoles 27-9. In the recent past, this would have been a perfect opportunity for Florida State to stumble. But with three conference victories in a row and the chance to head into the bye week halfway to the ACC's first 8-0 league record, look for the Seminoles to dispatch the offensively challenged Eagles. It would appear Chase Rettig will be back at quarterback for Boston College this week, which might be good for the Eagles' long-term prospects. A trip to Tallahassee, though, rarely bodes well for a young quarterback.
* Maryland at Clemson (Noon, ACC Network/Raycom): Tigers 27-17. With a commitment to Andre Ellington, the presence of an imposing defensive front and a dire need to climb back to .500 before the schedule turns particularly harsh in the second half, Clemson has the tools in place to upend the overachieving Terrapins. But Maryland has won its last two games in Death Valley under unusual circumstances, and no one should count out the possibility of a Terp upset. Chances are, though, this game says more about Clemson than Maryland in the long term.
* N.C. State at East Carolina (Noon, CBS College Sports): Wolfpack 45-34. Can you say four-hour game? There will be no shortage of passing in Greenville as the Pirates seek to salvage one of their games against ACC schools (they've already lost to Virginia Tech and North Carolina). Russell Wilson can be penciled in for another 300-yard day as the Wolfpack heads into its bye week with --- get this --- bowl eligibility.
* Miami at Duke (1, ESPN3.com): Hurricanes 34-21. It's going to take a bit for Miami to get well after Saturday's home shellacking at the hands of Florida State. A trip to Durham would normally help, and this one very well may. But the Blue Devils are coming off a bye, and at 2-3 with trips to Virginia Tech and Navy looming, could be facing a now-or-never moment. The final margin will be comfortable, but this could be scary for The U.
* Middle Tennessee at Georgia Tech (3:30, ESPN3.com): Yellow Jackets 34-17. With Anthony Allen coming off a huge day, the Yellow Jackets' offense is finally starting to look the way it is supposed to. The Blue Raiders are a tricky out, but Georgia Tech should gradually put away Dwight Dasher and friends over the first two or three quarters.
* Wake Forest at Virginia Tech (3:30, ESPNU): Hokies 38-20. Virginia Tech coach Frank Beamer has a fondness for remarking that he "knows what's real." Well, here's reality for Wake: It is highly unlikely the Demon Deacons will avoid limping into their bye week on a five-game losing streak. Tyrod Taylor, who is enjoying an especially strong senior season, should have no problems dissecting Wake Forest's suspect defense.
* North Carolina at Virginia (6, ESPN3.com): Cavaliers 16-10. Until the Tar Heels can win in Charlottesville for the first time since 1981, why not stick with the Cavaliers? Mike London's team has one upset in it this year, probably against a team dealing with some limitations on offense. That fits North Carolina, which has actually impressed despite its issues with suspensions on the way to a 3-2 start. A hiccup, though, might be looming.
Week 6: 4-2 (2-2 ACC)
Season record: 38-13 (9-5 ACC)
Preseason picks record: 38-13 (9-5 ACC)
Preseason picks changed in Week 7: None